AGGARWAL , NISHA and Kumar, Rajesh and SRIVASTVA , CHITRA and DUREJA , PREM and KHURANA , J. M. (2010) Synthesis of Nalidixic Acid Based Hydrazones as Novel Pesticides. Journal of Agricultural and Food Chemistry (ISSN: 0021-8561), 58 . pp. 3056-3061.
Restricted to Repository staff only
Thirty-one substituted hydrazones of nalidixic acid hydrazide were synthesized and characterized by spectral techniques. These compounds were evaluated for various biological activities, namely, fungicidal, insecticidal, and nitrification inhibitory activities. The antifungal activity was evaluated against five pathogenic fungi, namely, Rhizoctonia bataticola, Sclerotium rolfsii, Rhizoctonia solani, Fusarium oxysporum, and Alternaria porii. They showed maximum inihibition against A. porii with ED 50 = 34.2-151.3 μg/mL. The activity was comparable to that of a commercial fungicide, hexaconazole (ED 50 = 25.4 μg/mL). They were also screened for insecticidal activity against third-instar larvae of Spodoptera litura and adults of Callosobruchus maculatus and Tribollium castaneum. Most of them showed 70-100% mortality against S. litura through feeding method at 0.1% dose. These compounds were not found to be effective nitrification inhibitors.
|Uncontrolled Keywords:||Nalidixic acid; hydrazones; antifungal activity; insecticidal activity; nitrification inhibitory activity|
|Subjects:||Agricultural Sciences and Technology > Agricultural Chemicals|
|Deposited By:||Dr Rajesh Kumar|
|Deposited On:||07 Jul 2010 17:55|
|Last Modified:||07 Jul 2010 18:01|
Repository Staff Only: item control page